«Published at the World Wide Web of INTERNET on March 18th 2001.»
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COMPLEXITY IN DNA GENETIC CODE

M. Martín1, L. Trujillo1 and J. A. González2
1Laboratorio de Física y Química Computacional, Centro de Resonancia Magnética
Escuela de Física, Facultad de Ciencias
Universidad Central de Venezuela
2Laboratorio de Física Computacional, Centro de Física
Instituto Venezolano de Investigaciones Científicas
Postal Address: Apartado Postal 47586, Caracas 1041-A, Venezuela
mmartin@fisica.ciens.ucv.ve


[Poster presentation, American Physical Society Centennial Meeting, March 1999, Atlanta, Georgia, USA]


Abstract

In the present work, we propose a new method to characterize the complexity of the genetic code in DNA strands by using a specific measure of the entropy. The target DNA sequences were the same as those reported by Peng et al. in 1992, analyzing not only the original sequence but also its coding segments and proteins. Also intron-containing sequences were modified to simulate intron-less sequences for comparison. The results reveal that there is not a significant difference for the entropy measure between intron-containing and intron-less sequences, which seems to be in correspondence with other results. In the case of proteins, they exhibit a well defined behavior as a function of the length of the peptide chain. Further work is pursued to analyze a larger database even for nucleotide and aminoacid sequences.



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References

  1. Peng, C. K., S.V. Buldyrev, A.L. Goldberger, S. Havlin, F. Sciortino, M. Simons and H.E. Stanley, , Nature 356 (1992) 168.

  2. Berthelsen, C. L., J.A. Glazier and M.H. Skolnick, , Physical Review A 45 (1992) 8902.

  3. Voss, R. F., , Physical Review Letters 68 (1992) 3805.

  4. Buldyrev, S. V., A.L. Goldberger, S. Havlin, R.N. Mantegna, M.E. Matsa, C.K. Peng, M. Simons and H.E. Stanley, , Physical Review E 51 (1995) 5084.

[Web page manteined by Prof. Rafael Martín, updated on march 18th, 2001]


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