MICROVASCULAR PATHOLOGY IN THE SKELETAL MUSCLE PARANEOPLASTIC PHENOMENON

«Published at the World Wide Web of INTERNET on March 17th 2001.»
To go back click on the «Back» button at the button bar or go to the «return index» at the bottom of this page

MICROVASCULAR PATHOLOGY IN THE SKELETAL MUSCLE PARANEOPLASTIC PHENOMENON
H. J. Finol1, P. Tonino1, A. Márquez2, M. Correa1, B. Müller3 and L. Sosa4

1Center for Electron Microscopy, Faculty of Science,
2Institute of Experimental Medicine, Faculty of Medicine,
3Department of Physiology, Faculty of Dentistry,
4Department of Histology and Embriology, Faculty of Medicine,
Universidad Central de Venezuela
hfinol@electra.ciens.ucv.ve

[Published in the Journal of Submicroscopic Cytology and Pathology, 29 (1997) 1-3]


Abstract

An electron microscopic investigation was made in order to study capillary alterations in the muscle paraneoplastic phenomenon associated with different malignant tumors. Several abnormalities were found including basement membrane widening and lamination, endothelial hypertrophy, a varied degree of lumen oclusion, and proliferative changes in pericytes. A degenerative process leading to capillary necrosis was also observed. A mononuclear cell infiltrate formed by macrophages, lymohocytes and mast cells was seen. The capillary changes observed suggest the existence of an autoimmune vascular factor in the etiopathogenesis of muscle damage in this phenomenon.


References

  1. Abeloff, M. D., Paraneoplastic Syndromes. A Window on the Biology of Cancer, New England Journal of Medicine 317 (1987) 1598-1600.

  2. Finol, H. J., B. Müller, B. S. H. Torres, J. J. Domínguez, P. Perdomo and I. Montes de Oca, Ultrastructural Abnormalities in Muscular Vessels of Hyperthyroid Patients, Acta Neuropathologica, 71 (1986) 64-69.

  3. Finol, H. J., B. Müller, I. Montes de Oca and A. Márquez, Ultrastructure of skeletal muscle in rheumatoid myositis, Journal of Rheumatology 15 (1988) 552-555.

  4. Finol, H. J., S. Montagnani, A. Márquez, I. Montes de Oca and B. Müller, Ultrastructural Pathology of Skeletal Muscle in Systemic Lupus Erythematosus, Journal of Rheumatology 17 (1990) 210-219.

  5. Finol, H. J., A. Márquez, I. Rodríguez, I. Montes de Oca, P. Tonino and B. Müller, Neuromuscular Pathology in the Paraneoplastic Phenomenon Associated with Cervix Carcinoma, Journal of Experimental Clinical Cancer Research 12 (1993) 53-58.

  6. Finol, H. J., A. Márquez, H. Rivera, I. Montes de Oca and B. Müller, Ultrastructure of Systemic Sclerosis Inflammatory Myopathy, Journal of Submicroscopic Cytology and Pathology 26 (1994) 245-253.

  7. Grunwald, G. B., R. Klein, M. A. Symmonds and S. E. Kornguth, Autoimmune Basis for Visual Paraneoplastic Syndrome in Patients with Small-Cell Lung Carcinoma, Lancet 1 (1985) 658-661.

  8. Jerusalem, F., The Microcirculation of Muscle. In: Myology Basic and Clinical, A. G. Engel and C. Franzini-Armstrong (Editors), McGraw-Hill, New York, New York, USA, 1994, pp. 361-374.

  9. Jerusalem, F., M. Rakusa, A. G. Engel and R. D. McDonald, Morphometric Analysis of Skeletal Muscle Capillary Ultrastructure in Inflammatory Myopathies, Journal of Neurological Science 23 (1974) 391-402.

  10. Oursler, J. R., R. S. Labib, L. Ariss-Abdo, T. Burke, E. J. O'Kefee and G. J. Anhalt, Human Autoantibodies against Desmoplakins in Paraneoplastic Phenomenon, Journal of Clinical Investigation 89 (1992) 1775-1782.

  11. Pallis, M., N. Hopkinson, J. Lowe and R. Powell, An Electron Microscopic Study of Muscle Capillary Wall in Systemic Lupus Erythematosus, Lupus 3 (1994) 401-407.

  12. Tonino P., H. J. Finol, A Márquez and J. Prieto, Ultrastructural Pathology of Skeketal Muscle in the Paraneoplastic Phenomenon, Journal of Experimental Clinical Cancer Research 10 (1991) 283-289.

  13. Yamada, M., A. Inaba, M. Yamawaki, K. Ishida, T. Yokota, T. Uchihara, Y. Eishi and R. okeda, Paraneoplastic Encephalo-Myelo-Ganglionitis: Cellular Binding Sites of Antineural Antibodies, Acta Neuropathologica 88 (1994) 85-92.

[Web page manteined by Prof. Rafael Martín, updated on march 17th, 2001]

to continue ...
To go back click on the «Back» button at the button bar ...
Click here to go back to the Medical Physics Graduate Course Home Page

Click here to go back to the Physics Graduate Course Home Page

Click here to go back to the Instrumentation Graduate Course Home Page

Click here to go back to the School of Physics Home Page

Click here to go back to the Center for Magnetic Resonance Home Page

Click here to go back to the Laboratory for Statistical Physics and Collective Phenomena Home Page